A Barboursville business suffered substantial damage after a fire Tuesday morning, firefighters said.The fire was reported in the 6300 block of U.S. 60 at a building that holds multiple businesses. Firefighters two businesses suffered minimal damage from the fire, but one had substantial damage and is closed.Barboursville firefighters were joined by Ohio River Road VFD, Green Valley VFD, Ona VFD and Milton VFD at the scene.